p38 MAPK in MDS

p38 MAPK in MDS

(MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as " low-risk " and " high-risk " syndromes on the basis of their risk of progression to acute leukemia. Although progression to leukemia is the most common cause of death in high-risk patients, infectio...

p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitog...

p38 mapk and pi3k/akt signalling cascades in parkinson’s disease

parkinson's disease (pd) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring alzheimer's disease (ad). currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of pd. out of several factors contributing to pd prognosis, the role of p38 mapks (mitog...

Regulation of p38 MAPK by MAPK Kinases

SnapShot: p38 MAPK Substrates

Tr an sc ri p tio n fa ct o r ATF2 T69P, T71P Endogenous + yes CoIP Activation of transcription C/EBPβ n/d Overexpressed + n/d Activation of transcription CHOP-GADD153-DDIT3 S79P, S82P Endogenous + yes Activation of transcription ERa-ESR1 T311A Endogenous +/yes Activation of transcription Fos–c-fos T325P Overexpressed + yes Activation of transcription FOXO3a S7P Overexpressed + n/d CoIP Nuclear...